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PDBsum entry 3ods

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protein ligands links
Protein binding PDB id
3ods
Jmol
Contents
Protein chain
320 a.a. *
Ligands
EDO ×2
Waters ×208
* Residue conservation analysis
PDB id:
3ods
Name: Protein binding
Title: Crystal structure of the k185a mutant of the n-terminal doma human symplekin
Structure: Symplekin. Chain: a. Fragment: n-terminal domain. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sympk, spk. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.90Å     R-factor:   0.179     R-free:   0.231
Authors: L.Tong,K.Xiang
Key ref: K.Xiang et al. (2010). Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature, 467, 729-733. PubMed id: 20861839
Date:
11-Aug-10     Release date:   06-Oct-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q92797  (SYMPK_HUMAN) -  Symplekin
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1274 a.a.
320 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     histone mRNA 3'-end processing   1 term 

 

 
Nature 467:729-733 (2010)
PubMed id: 20861839  
 
 
Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
K.Xiang, T.Nagaike, S.Xiang, T.Kilic, M.M.Beh, J.L.Manley, L.Tong.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21292162 S.Danckwardt, A.S.Gantzert, S.Macher-Goeppinger, H.C.Probst, M.Gentzel, M.Wilm, H.J.Gröne, P.Schirmacher, M.W.Hentze, and A.E.Kulozik (2011).
p38 MAPK controls prothrombin expression by regulated RNA 3' end processing.
  Mol Cell, 41, 298-310.  
21329879 T.Nagaike, C.Logan, I.Hotta, O.Rozenblatt-Rosen, M.Meyerson, and J.L.Manley (2011).
Transcriptional activators enhance polyadenylation of mRNA precursors.
  Mol Cell, 41, 409-418.  
21204787 Y.Zhang, M.Zhang, and Y.Zhang (2011).
Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue.
  Biochem J, 434, 435-444.
PDB codes: 3omw 3omx
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.