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PDBsum entry 3odl

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protein Protein-protein interface(s) links
Isomerase/immunosuppressant PDB id
3odl
Jmol
Contents
Protein chains
(+ 4 more) 165 a.a. *
(+ 4 more) 11 a.a. *
Waters ×1726
* Residue conservation analysis
PDB id:
3odl
Name: Isomerase/immunosuppressant
Title: Crystal structure of cyclophilin a in complex with voclospor isa247
Structure: Cyclophilin a. Chain: a, c, e, g, i, k, m, o, q, s. Synonym: peptidyl-prolyl cis-trans isomerase. Engineered: yes. Voclosporin. Chain: b, d, f, h, j, l, n, p, r, t. Synonym: z-isa247, isatx-247, luveniq. Engineered: yes. Other_details: a modified cyclosporin a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppia. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Tolypocladium inflatum. Organism_taxid: 29910
Resolution:
2.31Å     R-factor:   0.171     R-free:   0.207
Authors: A.Kuglstatter,M.Stihle,J.Benz,M.Hennig
Key ref: A.Kuglstatter et al. (2011). Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin). Acta Crystallogr D Biol Crystallogr, 67, 119-123. PubMed id: 21245533
Date:
11-Aug-10     Release date:   16-Feb-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P62937  (PPIA_HUMAN) -  Peptidyl-prolyl cis-trans isomerase A
Seq:
Struc:
165 a.a.
165 a.a.
Protein chains
No UniProt id for this chain
Struc: 11 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, C, E, G, I, K, M, O, Q, S: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   8 terms 
  Biological process     viral reproduction   18 terms 
  Biochemical function     protein binding     7 terms  

 

 
    Added reference    
 
 
Acta Crystallogr D Biol Crystallogr 67:119-123 (2011)
PubMed id: 21245533  
 
 
Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).
A.Kuglstatter, F.Mueller, E.Kusznir, B.Gsell, M.Stihle, R.Thoma, J.Benz, L.Aspeslet, D.Freitag, M.Hennig.
 
  ABSTRACT  
 
No abstract given.