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PDBsum entry 3oaw

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protein ligands links
Transferase/transferase inhibitor PDB id
3oaw
Jmol
Contents
Protein chain
841 a.a. *
Ligands
OAW
Waters ×29
* Residue conservation analysis
PDB id:
3oaw
Name: Transferase/transferase inhibitor
Title: 4-methylpteridineones as orally active and selective pi3k/mt inhibitors
Structure: Phosphatidylinositol-4,5-bisphosphate 3-kinase ca subunit gamma isoform. Chain: a. Fragment: unp residues 144-1102. Synonym: ptdins-3-kinase subunit gamma, pi3-kinase subunit pi3k-gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma, ptdins-3-kinase subunit p110-gamma pi3k. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3cg. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
2.75Å     R-factor:   0.210     R-free:   0.268
Authors: D.R.Knighton,S.E.Greasley,C.M.-L.Rodgers
Key ref: K.K.Liu et al. (2010). 4-Methylpteridinones as orally active and selective pi3k/mtor dual inhibitors.. Bioorg.Med.Chem.Lett., 20, 6096. PubMed id: 20817449
Date:
05-Aug-10     Release date:   22-Sep-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P48736  (PK3CG_HUMAN) -  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1102 a.a.
841 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: E.C.2.7.1.153  - Phosphatidylinositol-4,5-bisphosphate 3-kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
1-Phosphatidyl-myo-inositol Metabolism
      Reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP
+ 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
=
ADP
Bound ligand (Het Group name = OAW)
matches with 45.00% similarity
+ 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
   Enzyme class 3: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     phosphatidylinositol-mediated signaling   2 terms 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     2 terms