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PDBsum entry 3oag

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protein ligands Protein-protein interface(s) links
Hydrolase / hydrolase inhibitor PDB id
3oag
Jmol
Contents
Protein chains
162 a.a. *
171 a.a. *
Ligands
NAG ×2
LPQ ×2
Waters ×180
* Residue conservation analysis
PDB id:
3oag
Name: Hydrolase / hydrolase inhibitor
Title: Design and optimization of new piperidines as renin inhibito
Structure: Renin. Chain: a, c. Fragment: renin (unp residue 67-232). Engineered: yes. Renin. Chain: b, d. Fragment: renin (unp residue 237-406). Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Resolution:
2.30Å     R-factor:   0.202     R-free:   0.259
Authors: L.Prade
Key ref: O.Corminboeuf et al. (2010). Design and optimization of new piperidines as renin inhibitors. Bioorg Med Chem Lett, 20, 6286-6290. PubMed id: 20843686
Date:
05-Aug-10     Release date:   03-Nov-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00797  (RENI_HUMAN) -  Renin
Seq:
Struc:
406 a.a.
162 a.a.
Protein chains
Pfam   ArchSchema ?
P00797  (RENI_HUMAN) -  Renin
Seq:
Struc:
406 a.a.
171 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.3.4.23.15  - Renin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Cleaves Leu-|- bond in angiotensinogen to generate angiotensin I.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     proteolysis   1 term 
  Biochemical function     aspartic-type endopeptidase activity     1 term  

 

 
Bioorg Med Chem Lett 20:6286-6290 (2010)
PubMed id: 20843686  
 
 
Design and optimization of new piperidines as renin inhibitors.
O.Corminboeuf, O.Bezençon, C.Grisostomi, L.RemeĊˆ, S.Richard-Bildstein, D.Bur, L.Prade, P.Hess, P.Strickner, W.Fischli, B.Steiner, A.Treiber.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21429746 R.Aspiotis, A.Chen, E.Cauchon, D.Dubé, J.P.Falgueyret, S.Gagné, M.Gallant, E.L.Grimm, R.Houle, H.Juteau, P.Lacombe, S.Laliberté, J.F.Lévesque, D.MacDonald, D.McKay, M.D.Percival, P.Roy, S.M.Soisson, and T.Wu (2011).
The discovery and synthesis of potent zwitterionic inhibitors of renin.
  Bioorg Med Chem Lett, 21, 2430-2436.  
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