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PDBsum entry 3o9j

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protein ligands metals links
Hydrolase PDB id
3o9j
Jmol
Contents
Protein chain
387 a.a.
Ligands
RP6
NDG
Metals
_CA
Waters ×320
PDB id:
3o9j
Name: Hydrolase
Title: Influenza na in complex with compound 5
Structure: Neuraminidase. Chain: a. Fragment: unp residues 81-467. Ec: 3.2.1.18
Source: Influenza a virus (a/duck/ukraine/1/19 ). Organism_taxid: 385580. Strain: a/duck/ukraine/1/1963 h3n8
Resolution:
2.00Å     R-factor:   0.218     R-free:   0.282
Authors: R.J.Russell,P.S.Kerry
Key ref: S.Rudrawar et al. (2010). Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat Commun, 1, 113-113. PubMed id: 21081911
Date:
04-Aug-10     Release date:   15-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q07599  (NRAM_I63A3) -  Neuraminidase
Seq:
Struc:
470 a.a.
387 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.2.1.18  - Exo-alpha-sialidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   3 terms 
  Biological process     carbohydrate metabolic process   1 term 
  Biochemical function     exo-alpha-sialidase activity     1 term  

 

 
Nat Commun 1:113-113 (2010)
PubMed id: 21081911  
 
 
Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
S.Rudrawar, J.C.Dyason, M.A.Rameix-Welti, F.J.Rose, P.S.Kerry, R.J.Russell, S.van der Werf, R.J.Thomson, N.Naffakh, M.von Itzstein.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21489803 A.Albohy, S.Mohan, R.B.Zheng, B.M.Pinto, and C.W.Cairo (2011).
Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes.
  Bioorg Med Chem, 19, 2817-2822.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.