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PDBsum entry 3o8u

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protein ligands links
Transferase PDB id
3o8u
Jmol
Contents
Protein chain
332 a.a. *
Ligands
BMU
BOG
Waters ×203
* Residue conservation analysis
PDB id:
3o8u
Name: Transferase
Title: Conformational plasticity of p38 map kinase dfg motif mutant response to inhibitor binding
Structure: Mitogen-activated protein kinase 14. Chain: a. Fragment: kinase domain. Synonym: map kinase 14, mapk 14, mitogen-activated protein alpha, map kinase p38 alpha, cytokine suppressive anti-infl drug-binding protein, csaid-binding protein, csbp, max-inte protein 2, map kinase mxi2, sapk2a. Engineered: yes. Mutation: yes
Source: Homo sapiens. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2
Resolution:
2.10Å     R-factor:   0.224     R-free:   0.285
Authors: H.V.Namboodiri,M.Karpusas,M.Bukhtiyarova,E.B.Springman
Key ref: H.V.Namboodiri et al. Conformational plasticity of p38 map kinase dfg motif mutants in response to inhibitor binding. To be published, .
Date:
03-Aug-10     Release date:   01-Sep-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
332 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms