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PDBsum entry 3o2u
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Contents |
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* Residue conservation analysis
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PDB id:
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Ligase
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Title:
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S. Cerevisiae ubc12
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Structure:
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Nedd8-conjugating enzyme ubc12. Chain: a, b. Synonym: rub1-conjugating enzyme, rub1-protein ligase, ubiquitin carrier protein 12. Engineered: yes
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Source:
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Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Gene: ubc12, ylr306w, l2142.3. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.00Å
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R-factor:
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0.187
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R-free:
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0.233
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Authors:
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D.C.Scott,J.K.Monda,C.R.R.Grace,D.M.Duda,R.W.Kriwacki,T.Kurz, B.A.Schulman
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Key ref:
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D.C.Scott
et al.
(2010).
A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol Cell,
39,
784-796.
PubMed id:
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Date:
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22-Jul-10
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Release date:
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15-Sep-10
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PROCHECK
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Headers
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References
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P52491
(UBC12_YEAST) -
NEDD8-conjugating enzyme UBC12 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
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Seq:
Struc:
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188 a.a.
190 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.3.2.34
- E2 NEDD8-conjugating enzyme.
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Reaction:
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[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8- conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
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Mol Cell
39:784-796
(2010)
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PubMed id:
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A dual E3 mechanism for Rub1 ligation to Cdc53.
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D.C.Scott,
J.K.Monda,
C.R.Grace,
D.M.Duda,
R.W.Kriwacki,
T.Kurz,
B.A.Schulman.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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M.F.Calabrese,
D.C.Scott,
D.M.Duda,
C.R.Grace,
I.Kurinov,
R.W.Kriwacki,
and
B.A.Schulman
(2011).
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
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Nat Struct Mol Biol,
18,
947-949.
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PDB code:
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S.Rahighi,
and
I.Dikic
(2011).
Conformational flexibility and rotation of the RING domain in activation of cullin-RING ligases.
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Nat Struct Mol Biol,
18,
863-865.
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C.S.Hwang,
A.Shemorry,
D.Auerbach,
and
A.Varshavsky
(2010).
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
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Nat Cell Biol,
12,
1177-1185.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
