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PDBsum entry 3nup

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protein ligands links
Transferase/transferase inhibitor PDB id
3nup
Jmol
Contents
Protein chain
252 a.a. *
Ligands
3NU
Waters ×24
* Residue conservation analysis
PDB id:
3nup
Name: Transferase/transferase inhibitor
Title: Cdk6 (monomeric) in complex with inhibitor
Structure: Cell division protein kinase 6. Chain: a. Fragment: unp residues 1-301. Synonym: serine/threonine-protein kinase plstire. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
2.60Å     R-factor:   0.238     R-free:   0.264
Authors: R Chopra
Key ref: Y.S.Cho et al. (2010). 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem, 53, 7938-7957. PubMed id: 21038853 DOI: 10.1021/jm100571n
Date:
07-Jul-10     Release date:   22-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q00534  (CDK6_HUMAN) -  Cyclin-dependent kinase 6
Seq:
Struc:
326 a.a.
252 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell projection   7 terms 
  Biological process     type B pancreatic cell development   35 terms 
  Biochemical function     nucleotide binding     10 terms  

 

 
    reference    
 
 
DOI no: 10.1021/jm100571n J Med Chem 53:7938-7957 (2010)
PubMed id: 21038853  
 
 
4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
Y.S.Cho, M.Borland, C.Brain, C.H.Chen, H.Cheng, R.Chopra, K.Chung, J.Groarke, G.He, Y.Hou, S.Kim, S.Kovats, Y.Lu, M.O'Reilly, J.Shen, T.Smith, G.Trakshel, M.Vögtle, M.Xu, M.Xu, M.J.Sung.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22199876 A.Ertan, P.Sharma, D.Nagaraju, K.Deepthi, and S.G.Manjunatha (2011).
(2R)-4-[(9H-Fluoren-9-ylmeth-oxy)carbon-yl]-2-methyl-piperazin-1-ium chloride.
  Acta Crystallogr Sect E Struct Rep Online, 67, o3386-o3387.  
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