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PDBsum entry 3nua

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protein ligands Protein-protein interface(s) links
Ligase PDB id
3nua
Jmol
Contents
Protein chains
236 a.a. *
Ligands
ADP ×3
AMP
CIT ×2
GOL
Waters ×711
* Residue conservation analysis
PDB id:
3nua
Name: Ligase
Title: Crystal structure of phosphoribosylaminoimidazole-succinocar synthase from clostridium perfringens
Structure: Phosphoribosylaminoimidazole-succinocarboxamide s chain: a, b. Synonym: saicar synthetase. Engineered: yes
Source: Clostridium perfringens. Organism_taxid: 195103. Strain: atcc 13124. Gene: cpf_0673, purc. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
1.40Å     R-factor:   0.144     R-free:   0.161
Authors: Y.Kim,R.Mulligan,K.Kwon,W.F.Anderson,A.Joachimiak
Key ref: Y.Kim et al. Crystal structure of phosphoribosylaminoimidazole-Succinocarboxamide synth from clostridium perfringens. To be published, .
Date:
06-Jul-10     Release date:   25-Aug-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q0TTB4  (PUR7_CLOP1) -  Phosphoribosylaminoimidazole-succinocarboxamide synthase
Seq:
Struc:
235 a.a.
236 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.3.2.6  - Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Purine Biosynthesis (late stages)
      Reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate
ATP
+ 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
+
L-aspartate
Bound ligand (Het Group name = CIT)
matches with 57.14% similarity
=
ADP
Bound ligand (Het Group name = ADP)
corresponds exactly
+ phosphate
+ (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     purine nucleotide biosynthetic process   2 terms 
  Biochemical function     nucleotide binding     4 terms