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PDBsum entry 3ntb

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
3ntb
Jmol
Contents
Protein chains
552 a.a. *
Ligands
HEM ×4
NAG ×8
NAG-NAG-NAG ×4
BOG ×6
T1N ×4
Waters ×1109
* Residue conservation analysis
PDB id:
3ntb
Name: Oxidoreductase
Title: Structure of 6-methylthio naproxen analog bound to mcox-2.
Structure: Prostaglandin-endoperoxide synthase 2. Chain: a, b, c, d. Fragment: unp residues 18-604, catalytic domain. Engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: cox-2 pghs-b, mcg_5001, ptgs2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
2.27Å     R-factor:   0.235     R-free:   0.266
Authors: K.C.Duggan,J.Musee,M.J.Walters,J.M.Harp,J.R.Kiefer,J.A.Oates L.J.Marnett
Key ref: K.C.Duggan et al. (2010). Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem, 285, 34950-34959. PubMed id: 20810665
Date:
03-Jul-10     Release date:   01-Sep-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q05769  (PGH2_MOUSE) -  Prostaglandin G/H synthase 2
Seq:
Struc:
 
Seq:
Struc:
604 a.a.
552 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.14.99.1  - Prostaglandin-endoperoxide synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Arachidonate
+ AH(2)
+ 2 × O(2)
= prostaglandin H(2)
+
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     protein complex   9 terms 
  Biological process     maintenance of blood-brain barrier   64 terms 
  Biochemical function     lipid binding     10 terms  

 

 
    reference    
 
 
J Biol Chem 285:34950-34959 (2010)
PubMed id: 20810665  
 
 
Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
K.C.Duggan, M.J.Walters, J.Musee, J.M.Harp, J.R.Kiefer, J.A.Oates, L.J.Marnett.
 
  ABSTRACT  
 
No abstract given.