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PDBsum entry 3nt1

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase PDB id
3nt1
Jmol
Contents
Protein chains
552 a.a. *
Ligands
NAG ×4
NAG-NAG ×2
BOG ×4
NPS ×2
HEM ×2
Metals
_CL ×2
Waters ×1051
* Residue conservation analysis
PDB id:
3nt1
Name: Oxidoreductase
Title: High resolution structure of naproxen:cox-2 complex.
Structure: Prostaglandin-endoperoxide synthase 2. Chain: a, b. Fragment: unp residues 18-604, catalytic domain. Engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: cox-2 pghs-b, mcg_5001, ptgs2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
1.73Å     R-factor:   0.168     R-free:   0.186
Authors: K.C.Duggan,J.Musee,M.J.Walters,J.M.Harp,J.R.Kiefer,J.A.Oates L.J.Marnett
Key ref: K.C.Duggan et al. (2010). Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem, 285, 34950-34959. PubMed id: 20810665 DOI: 10.1074/jbc.M110.162982
Date:
02-Jul-10     Release date:   01-Sep-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q05769  (PGH2_MOUSE) -  Prostaglandin G/H synthase 2
Seq:
Struc:
 
Seq:
Struc:
604 a.a.
552 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     protein complex   9 terms 
  Biological process     maintenance of blood-brain barrier   64 terms 
  Biochemical function     lipid binding     10 terms  

 

 
DOI no: 10.1074/jbc.M110.162982 J Biol Chem 285:34950-34959 (2010)
PubMed id: 20810665  
 
 
Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
K.C.Duggan, M.J.Walters, J.Musee, J.M.Harp, J.R.Kiefer, J.A.Oates, L.J.Marnett.
 
  ABSTRACT  
 
No abstract given.