PDBsum entry 3nms

Immune system

PDB id: 3nms

Contents

Protein chains

641 a.a. *

294 a.a. *

84 a.a. *

184 a.a. *

Ligands

NAG

* Residue conservation analysis

PDB id:

3nms

Name:

Immune system

Title:

Staphylococcal complement inhibitor (scin) in complex with human complement c3c

Structure:

Complement c3. Chain: a. Complement c3. Chain: c. Staphylococcal complement inhibitor. Chain: m. Synonym: scin. Engineered: yes. Complement c3.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Other_details: serum. Staphylococcus aureus. Organism_taxid: 158878. Strain: mu50 / atcc 700699. Gene: sav1942, scn. Expressed in: escherichia coli.

Resolution:

4.10Å R-factor: 0.273 R-free: 0.289

Authors:

B.V.Geisbrecht,B.L.Garcia

Key ref:

B.L.Garcia et al. (2010). Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. J Mol Biol, 402, 17-29. PubMed id: 20654625

Date:

22-Jun-10 Release date: 04-Aug-10

Protein chain

P01024  (CO3_HUMAN) -  Complement C3 from Homo sapiens

Seq: 1663 a.a.

Struc: 641 a.a.

Protein chain

P01024  (CO3_HUMAN) -  Complement C3 from Homo sapiens

Seq: 1663 a.a.

Struc: 294 a.a.

Protein chain

Q931M7  (SCIN_STAAM) -  Staphylococcal complement inhibitor from Staphylococcus aureus (strain Mu50 / ATCC 700699)

Seq: 116 a.a.

Struc: 84 a.a.

Protein chain

P01024  (CO3_HUMAN) -  Complement C3 from Homo sapiens

Seq: 1663 a.a.

Struc: 184 a.a.

J Mol Biol 402:17-29 (2010)

PubMed id: 20654625

Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.

B.L.Garcia, K.X.Ramyar, A.Tzekou, D.Ricklin, W.J.McWhorter, J.D.Lambris, B.V.Geisbrecht.

ABSTRACT

No abstract given.