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PDBsum entry 3nks

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protein ligands links
Oxidoreductase/oxidoreductase inhibitor PDB id
3nks
Jmol
Contents
Protein chain
465 a.a.
Ligands
ACJ
FAD
GOL ×2
Waters ×269
PDB id:
3nks
Name: Oxidoreductase/oxidoreductase inhibitor
Title: Structure of human protoporphyrinogen ix oxidase
Structure: Protoporphyrinogen oxidase. Chain: a. Synonym: protoporphyrinogen ix oxidase, ppo. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppox. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.90Å     R-factor:   0.206     R-free:   0.232
Authors: Y.Shen
Key ref: X.Qin et al. (2011). Structural insight into human variegate porphyria disease. FASEB J, 25, 653-664. PubMed id: 21048046 DOI: 10.1096/fj.10-170811
Date:
21-Jun-10     Release date:   20-Apr-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P50336  (PPOX_HUMAN) -  Protoporphyrinogen oxidase
Seq:
Struc:
477 a.a.
465 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.3.3.4  - Protoporphyrinogen oxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Porphyrin Biosynthesis (later stages)
      Reaction: Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2
Protoporphyrinogen-IX
+ 3 × O(2)
= protoporphyrin-IX
+ 3 × H(2)O(2)
      Cofactor: FAD
FAD
Bound ligand (Het Group name = FAD) corresponds exactly
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   7 terms 
  Biological process     small molecule metabolic process   8 terms 
  Biochemical function     oxidoreductase activity     3 terms  

 

 
    reference    
 
 
DOI no: 10.1096/fj.10-170811 FASEB J 25:653-664 (2011)
PubMed id: 21048046  
 
 
Structural insight into human variegate porphyria disease.
X.Qin, Y.Tan, L.Wang, Z.Wang, B.Wang, X.Wen, G.Yang, Z.Xi, Y.Shen.
 
  ABSTRACT  
 
No abstract given.