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PDBsum entry 3nfl

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protein ligands Protein-protein interface(s) links
Protein binding PDB id
3nfl
Jmol
Contents
Protein chains
92 a.a.
89 a.a.
89 a.a.
Ligands
ILE-GLU-SER-ASP-
VAL
×4
Waters ×167
PDB id:
3nfl
Name: Protein binding
Title: Crystal structure of the ptpn4 pdz domain complexed with the terminus of the glun2a nmda receptor subunit
Structure: Tyrosine-protein phosphatase non-receptor type 4. Chain: a, b, c, d. Fragment: pdz domain (unp residues 499-604). Synonym: protein-tyrosine phosphatase meg1, ptpase-meg1, me engineered: yes. Glutamate [nmda] receptor subunit epsilon-1. Chain: e, f, g, h. Fragment: unp residues 1449-1464. Synonym: n-methyl d-aspartate receptor subtype 2a, nmdar2a,
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn4. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: nr2a16 peptide has been chemically synthetiz sequence ocuurs naturally in homo sapiens (human)
Resolution:
1.91Å     R-factor:   0.218     R-free:   0.246
Authors: N.Babault,F.Cordier,M.Lafage,J.Cockburn,A.Haouz,F.A.Rey,M.De H.Buc,M.Lafon,N.Wolff
Key ref: N.Babault et al. (2011). Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death. Structure, 19, 1518-1524. PubMed id: 22000519 DOI: 10.1016/j.str.2011.07.007
Date:
10-Jun-10     Release date:   24-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P29074  (PTN4_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 4
Seq:
Struc:
 
Seq:
Struc:
926 a.a.
92 a.a.
Protein chain
Pfam   ArchSchema ?
P29074  (PTN4_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 4
Seq:
Struc:
 
Seq:
Struc:
926 a.a.
89 a.a.
Protein chain
Pfam   ArchSchema ?
P29074  (PTN4_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 4
Seq:
Struc:
 
Seq:
Struc:
926 a.a.
89 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
DOI no: 10.1016/j.str.2011.07.007 Structure 19:1518-1524 (2011)
PubMed id: 22000519  
 
 
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death.
N.Babault, F.Cordier, M.Lafage, J.Cockburn, A.Haouz, C.Prehaud, F.A.Rey, M.Delepierre, H.Buc, M.Lafon, N.Wolff.
 
  ABSTRACT  
 
No abstract given.