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PDBsum entry 3new

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protein ligands links
Transferase/transferase inhibitor PDB id
3new
Jmol
Contents
Protein chain
334 a.a. *
Ligands
3NE
* Residue conservation analysis
PDB id:
3new
Name: Transferase/transferase inhibitor
Title: P38-alpha complexed with compound 10
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, mitogen-activated protein alpha, map kinase p38 alpha, cytokine suppressive anti-infl drug-binding protein, csaid-binding protein, csbp, max-inte protein 2, map kinase mxi2, sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.51Å     R-factor:   0.219     R-free:   0.306
Authors: E.R.Goedken,K.M.Comess,C.Sun,M.Argiriadi,Y.Jia,C.M.Quinn,D.L D.Marcotte,D.Borhani
Key ref: K.M.Comess et al. (2011). Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol, 6, 234-244. PubMed id: 21090814 DOI: 10.1021/cb1002619
Date:
09-Jun-10     Release date:   01-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
334 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
    reference    
 
 
DOI no: 10.1021/cb1002619 ACS Chem Biol 6:234-244 (2011)
PubMed id: 21090814  
 
 
Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
K.M.Comess, C.Sun, C.Abad-Zapatero, E.R.Goedken, R.J.Gum, D.W.Borhani, M.Argiriadi, D.R.Groebe, Y.Jia, J.E.Clampit, D.L.Haasch, H.T.Smith, S.Wang, D.Song, M.L.Coen, T.E.Cloutier, H.Tang, X.Cheng, C.Quinn, B.Liu, Z.Xin, G.Liu, E.H.Fry, V.Stoll, T.I.Ng, D.Banach, D.Marcotte, D.J.Burns, D.J.Calderwood, P.J.Hajduk.
 
  ABSTRACT  
 
No abstract given.