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PDBsum entry 3n8i

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protein ligands links
Hydrolase PDB id
3n8i
Jmol
Contents
Protein chain
154 a.a.
Ligands
NLA
Waters ×209
PDB id:
3n8i
Name: Hydrolase
Title: Crystal structure of the a isoform of human cytoplasmic prot tyrosine phosphatase (hcptp-a) in complex with 1-naphtylace
Structure: Low molecular weight phosphotyrosine protein phos chain: a. Synonym: lmw-ptpase, lmw-ptp, low molecular weight cytosoli phosphatase, red cell acid phosphatase 1, adipocyte acid ph engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acp1, apc1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.50Å     R-factor:   0.175     R-free:   0.203
Authors: K.T.Homan,D.Balasubramaniam,C.V.Stauffacher
Key ref: K.T.Homan et al. Structural characterization of a secondary binding si low molecular weight protein tyrosine phosphatases. To be published, .
Date:
28-May-10     Release date:   07-Dec-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24666  (PPAC_HUMAN) -  Low molecular weight phosphotyrosine protein phosphatase
Seq:
Struc:
158 a.a.
154 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: E.C.3.1.3.2  - Acid phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: A phosphate monoester + H2O = an alcohol + phosphate
phosphate monoester
+ H(2)O
= alcohol
+ phosphate
   Enzyme class 3: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   3 terms 
  Biological process     peptidyl-tyrosine dephosphorylation   2 terms 
  Biochemical function     protein binding     7 terms