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PDBsum entry 3n5o

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protein ligands Protein-protein interface(s) links
Transferase PDB id
3n5o
Jmol
Contents
Protein chains
228 a.a. *
214 a.a. *
Ligands
GSH
SO4 ×3
Waters ×460
* Residue conservation analysis
PDB id:
3n5o
Name: Transferase
Title: Crystal structure of putative glutathione transferase from coccidioides immitis bound to glutathione
Structure: Glutathione transferase. Chain: a, b. Engineered: yes
Source: Coccidioides immitis. Organism_taxid: 5501. Gene: coi. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.85Å     R-factor:   0.160     R-free:   0.205
Authors: Seattle Structural Genomics Center For Infectious Disease (S
Key ref: T.E.Edwards et al. (2011). Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis. Acta Crystallogr Sect F Struct Biol Cryst Commun, 67, 1038-1043. PubMed id: 21904047
Date:
25-May-10     Release date:   16-Jun-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
D2YW48  (GST_COCIM) -  Probable glutathione S-transferase
Seq:
Struc:
231 a.a.
228 a.a.
Protein chain
Pfam   ArchSchema ?
D2YW48  (GST_COCIM) -  Probable glutathione S-transferase
Seq:
Struc:
231 a.a.
214 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.2.5.1.18  - Glutathione transferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: RX + glutathione = HX + R-S-glutathione
RX
+
glutathione
Bound ligand (Het Group name = GSH)
corresponds exactly
= HX
+ R-S-glutathione
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     aromatic amino acid family metabolic process   1 term 
  Biochemical function     catalytic activity     3 terms  

 

 
    reference    
 
 
Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1038-1043 (2011)
PubMed id: 21904047  
 
 
Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis.
T.E.Edwards, C.M.Bryan, D.J.Leibly, S.H.Dieterich, J.Abendroth, B.Sankaran, D.Sivam, B.L.Staker, W.C.Van Voorhis, P.J.Myler, L.J.Stewart.
 
  ABSTRACT  
 
No abstract given.