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PDBsum entry 3myq

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protein ligands metals links
Lyase PDB id
3myq
Jmol
Contents
Protein chain
257 a.a. *
Ligands
MES
DMS ×2
E27
Metals
_ZN
Waters ×253
* Residue conservation analysis
PDB id:
3myq
Name: Lyase
Title: Crystal structure of human carbonic anhydrase isozyme ii wit chloro-5-[(1h-imidazo[4,5-c]quinolin-2-ylsulfanyl) acetyl]benzenesulfonamide
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratas carbonic anhydrasE C, cac. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.35Å     R-factor:   0.143     R-free:   0.181
Authors: S.Grazulis,E.Manakova,D.Golovenko
Date:
11-May-10     Release date:   02-Feb-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   22 terms 
  Biochemical function     protein binding     5 terms