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PDBsum entry 3mwq

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protein ligands links
Hydrolase PDB id
3mwq
Jmol
Contents
Protein chain
256 a.a.
Ligands
SO4 ×5
GOL ×2
Waters ×274
PDB id:
3mwq
Name: Hydrolase
Title: Crystal structure of ribonuclease a tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor
Structure: Ribonuclease pancreatic, linker, ribonuclease pan chain: a. Synonym: rnase 1, rnase a. Engineered: yes
Source: Bos taurus, synthetic, bos taurus. Organism_taxid: 9913, 32630, 9913. Gene: rns1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.68Å     R-factor:   0.176     R-free:   0.216
Authors: P.Neumann,F.Leich
Key ref: U.Arnold et al. (2011). Crystal structure of RNase A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor. FEBS J, 278, 331-340. PubMed id: 21134128
Date:
06-May-10     Release date:   09-Feb-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P61823  (RNAS1_BOVIN) -  Ribonuclease pancreatic
Seq:
Struc:
150 a.a.
256 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 25 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.27.5  - Pancreatic ribonuclease.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     nucleic acid binding     2 terms  

 

 
FEBS J 278:331-340 (2011)
PubMed id: 21134128  
 
 
Crystal structure of RNase A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor.
U.Arnold, F.Leich, P.Neumann, H.Lilie, R.Ulbrich-Hofmann.
 
  ABSTRACT  
 
No abstract given.