PDBsum entry 3mpl

Signaling protein

PDB id: 3mpl

Contents

Protein chain

233 a.a. *

Ligands

EDO ×2

Waters ×82

* Residue conservation analysis

PDB id:

3mpl

Name:

Signaling protein

Title:

Crystal structure of bordetella pertussis bvgs vft2 domain (double mutant f375e/q461e)

Structure:

Virulence sensor protein bvgs. Chain: a. Fragment: unp residues 287-542. Engineered: yes. Mutation: yes

Source:

Bordetella pertussis. Organism_taxid: 257313. Strain: tohamai. Gene: bp1877, bvgs. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.10Å R-factor: 0.191 R-free: 0.245

Authors:

J.Herrou,C.Bompard,R.Wintjens,E.Dupre,E.Willery,V.Villeret,C.Locht, R.Antoine,F.Jacob-Dubuisson

Key ref:

J.Herrou et al. (2010). Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism. Proc Natl Acad Sci U S A, 107, 17351-17355. PubMed id: 20855615

Date:

27-Apr-10 Release date: 06-Oct-10

Protein chain

P16575  (BVGS_BORPE) -  Virulence sensor protein BvgS from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

Seq: 1238 a.a.

Struc: 233 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.13.3 - histidine kinase.
• Reaction: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Proc Natl Acad Sci U S A 107:17351-17355 (2010)

PubMed id: 20855615

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism.

J.Herrou, C.Bompard, R.Wintjens, E.Dupré, E.Willery, V.Villeret, C.Locht, R.Antoine, F.Jacob-Dubuisson.

ABSTRACT

No abstract given.