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PDBsum entry 3mow

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protein ligands links
Hydrolase/hydrolase inhibitor PDB id
3mow
Jmol
Contents
Protein chain
254 a.a.
Ligands
B2B
Waters ×156
PDB id:
3mow
Name: Hydrolase/hydrolase inhibitor
Title: Crystal structure of shp2 in complex with a tautomycetin ana 1
Structure: Tyrosine-protein phosphatase non-receptor type 11 chain: a. Fragment: catalytic domain (unp residues 262-528). Synonym: protein-tyrosine phosphatase 2c, ptp-2c, protein-t phosphatase 1d, ptp-1d, sh-ptp3, sh-ptp2, shp-2, shp2. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptp2c, ptpn11, shptp2. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
2.30Å     R-factor:   0.170     R-free:   0.222
Authors: Z.-Y.Zhang,S.Liu,Z.Yu,X.Yu
Key ref: Z.-Y.Zhang et al. Crystal structure of shp2 in complex with a tautomyce analog ttn d-1. To be published, .
Date:
23-Apr-10     Release date:   04-May-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q06124  (PTN11_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 11
Seq:
Struc:
 
Seq:
Struc:
597 a.a.
254 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms  

 

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