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PDBsum entry 3mnh

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protein metals links
Proton transport PDB id
3mnh
Jmol
Contents
Protein chain
258 a.a. *
Metals
_NA
_ZN
Waters ×136
* Residue conservation analysis
PDB id:
3mnh
Name: Proton transport
Title: Human carbonic anhydrase ii mutant k170a
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratas carbonic anhydrasE C, cac. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.65Å     R-factor:   0.156     R-free:   0.188
Authors: J.F.Domsic,R.Mckenna
Key ref: J.F.Domsic et al. (2010). Structural and kinetic study of the extended active s proton transfer in human carbonic anhydrase ii.. Biochemistry, 49, 6394. PubMed id: 20578724
Date:
21-Apr-10     Release date:   14-Jul-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
258 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   21 terms 
  Biochemical function     protein binding     5 terms