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PDBsum entry 3mhm

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protein ligands metals links
Lyase/lyase inhibitor PDB id
3mhm
Jmol
Contents
Protein chain
257 a.a. *
Ligands
DMS
J75
Metals
_ZN
Waters ×291
* Residue conservation analysis
PDB id:
3mhm
Name: Lyase/lyase inhibitor
Title: Crystal structure of human carbonic anhydrase isozyme ii wit (6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesu
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratas carbonic anhydrasE C, cac. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.50Å     R-factor:   0.137     R-free:   0.187
Authors: S.Grazulis,E.Manakova,D.Golovenko
Key ref: J.Sūdžius et al. (2010). 4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII. Bioorg Med Chem, 18, 7413-7421. PubMed id: 20889345 DOI: 10.1016/j.bmc.2010.09.011
Date:
08-Apr-10     Release date:   20-Oct-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zinc
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   10 terms 
  Biological process     angiotensin-mediated signaling pathway   20 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
DOI no: 10.1016/j.bmc.2010.09.011 Bioorg Med Chem 18:7413-7421 (2010)
PubMed id: 20889345  
 
 
4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII.
J.Sūdžius, L.Baranauskienė, D.Golovenko, J.Matulienė, V.Michailovienė, J.Torresan, J.Jachno, R.Sukackaitė, E.Manakova, S.Gražulis, S.Tumkevičius, D.Matulis.
 
  ABSTRACT  
 
No abstract given.