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PDBsum entry 3mdz

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protein ligands metals links
Lyase PDB id
3mdz
Jmol
Contents
Protein chain
259 a.a. *
Ligands
EZL
GOL ×3
Metals
_ZN
Waters ×48
* Residue conservation analysis
PDB id:
3mdz
Name: Lyase
Title: Crystal structure of human carbonic anhydrase vii [isoform 1
Structure: Carbonic anhydrase 7. Chain: a. Fragment: residues in unp 24-281. Synonym: ca7, carbonic anhydrase vii, ca-vii, carbonate deh vii. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca7. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.32Å     R-factor:   0.203     R-free:   0.252
Authors: E.Ugochukwu,N.Shafqat,E.Pilka,A.Chaikuad,T.Krojer,J.Muniz,J. J.Bray,C.Bountra,C.H.Arrowsmith,J.Weigelt,A.Edwards,F.Von D E.P.Carpenter,W.W.Yue,U.Oppermann,Structural Genomics Conso (Sgc)
Key ref: E.Ugochukwu et al. Crystal structure of human carbonic anhydrase VII [is 1], Ca7. To be published, .
Date:
31-Mar-10     Release date:   23-Jun-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P43166  (CAH7_HUMAN) -  Carbonic anhydrase 7
Seq:
Struc:
264 a.a.
259 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   2 terms 
  Biological process     small molecule metabolic process   6 terms 
  Biochemical function     lyase activity     4 terms