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PDBsum entry 3mdj

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protein ligands metals Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3mdj
Jmol
Contents
Protein chain
818 a.a.
Ligands
BES ×3
NAG-NAG-BMA-MAN-
MAN
×2
NAG ×3
NAG-NAG
Metals
_ZN ×3
PDB id:
3mdj
Name: Hydrolase/hydrolase inhibitor
Title: Er aminopeptidase, erap1, bound to the zinc aminopeptidase i bestatin
Structure: Endoplasmic reticulum aminopeptidase 1. Chain: a, b, c. Fragment: unp residues 37-939. Synonym: adipocyte-derived leucine aminopeptidase, a-lap, a aminopeptidase pils, puromycin-insensitive leucyl-specific aminopeptidase, pils-ap, type 1 tumor necrosis factor recep shedding aminopeptidase regulator. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erap1, appils, arts1, kiaa0525, unq584/pro1154. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Resolution:
2.95Å     R-factor:   0.202     R-free:   0.264
Authors: T.T.Nguyen,L.J.Stern
Key ref: T.T.Nguyen et al. (2011). Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol, 18, 604-613. PubMed id: 21478864
Date:
30-Mar-10     Release date:   30-Mar-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9NZ08  (ERAP1_HUMAN) -  Endoplasmic reticulum aminopeptidase 1
Seq:
Struc:
 
Seq:
Struc:
941 a.a.
818 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   10 terms 
  Biological process     immune system process   11 terms 
  Biochemical function     protein binding     10 terms  

 

 
Nat Struct Mol Biol 18:604-613 (2011)
PubMed id: 21478864  
 
 
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1.
T.T.Nguyen, S.C.Chang, I.Evnouchidou, I.A.York, C.Zikos, K.L.Rock, A.L.Goldberg, E.Stratikos, L.J.Stern.
 
  ABSTRACT  
 
No abstract given.