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PDBsum entry 3m14

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protein ligands metals links
Lyase/lyase inhibitor PDB id
3m14
Jmol
Contents
Protein chain
257 a.a.
Ligands
BEV
BE7
Metals
_ZN
Waters ×255
PDB id:
3m14
Name: Lyase/lyase inhibitor
Title: Carbonic anhydrase ii in complex with novel sulfonamide inhi
Structure: Carbonic anhydrase 2. Chain: a. Fragment: carbonic anhydrase ii. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratas carbonic anhydrasE C, cac. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.38Å     R-factor:   0.127     R-free:   0.176
Authors: J.Schulze Wischeler,A.Heine,G.Klebe,N.U.Sandner
Key ref: J.Schulze wischeler et al. Structural investigation and inhibitor studies on car anhydrase ii. To be published, .
Date:
04-Mar-10     Release date:   25-May-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zinc
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   10 terms 
  Biological process     angiotensin-mediated signaling pathway   20 terms 
  Biochemical function     protein binding     5 terms