PDBsum entry 3ldw

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protein ligands metals Protein-protein interface(s) links
Transferase PDB id
Protein chains
358 a.a. *
ZOL ×4
IPE ×4
EDO ×2
GOL ×3
_MG ×12
Waters ×562
* Residue conservation analysis
PDB id:
Name: Transferase
Title: Crystal structure of plasmodium vivax geranylgeranylpyrophos synthase pvx_092040 with zoledronate and ipp bound
Structure: Farnesyl pyrophosphate synthase. Chain: a, b, c, d. Engineered: yes
Source: Plasmodium vivax. Organism_taxid: 126793. Strain: salvador i. Gene: pvx_092040. Expressed in: escherichia coli. Expression_system_taxid: 562.
2.47Å     R-factor:   0.241     R-free:   0.286
Authors: A.K.Wernimont,J.Lew,Y.Zhao,I.Kozieradzki,D.Cossar,M.Schapira A.Bochkarev,C.H.Arrowsmith,C.Bountra,J.Weigelt,A.M.Edwards, J.D.Artz,Structural Genomics Consortium (Sgc)
Key ref: J.D.Artz et al. (2011). Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J Biol Chem, 286, 3315-3322. PubMed id: 21084289
13-Jan-10     Release date:   17-Nov-10    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
A5K4U6  (A5K4U6_PLAVS) -  Farnesyl pyrophosphate synthase, putative
375 a.a.
358 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     isoprenoid biosynthetic process   1 term 
  Biochemical function     transferase activity     2 terms  


J Biol Chem 286:3315-3322 (2011)
PubMed id: 21084289  
Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
J.D.Artz, A.K.Wernimont, J.E.Dunford, M.Schapira, A.Dong, Y.Zhao, J.Lew, R.G.Russell, F.H.Ebetino, U.Oppermann, R.Hui.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
22868759 J.A.Bell, K.L.Ho, and R.Farid (2012).
Significant reduction in errors associated with nonbonded contacts in protein crystal structures: automated all-atom refinement with PrimeX.
  Acta Crystallogr D Biol Crystallogr, 68, 935-952.  
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