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PDBsum entry 3kok

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protein metals links
Lyase PDB id
3kok
Jmol
Contents
Protein chain
258 a.a. *
Metals
_CO
Waters ×223
* Residue conservation analysis
PDB id:
3kok
Name: Lyase
Title: Crystal structure of cobalt (ii) human carbonic anhydrase ii
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratas carbonic anhydrasE C, cac. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
1.50Å     R-factor:   0.200     R-free:   0.227
Authors: B.S.Avvaru
Key ref: B.S.Avvaru et al. (2010). Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II. Arch Biochem Biophys, 502, 53-59. PubMed id: 20637176 DOI: 10.1016/j.abb.2010.07.010
Date:
13-Nov-09     Release date:   25-Aug-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
258 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   21 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
DOI no: 10.1016/j.abb.2010.07.010 Arch Biochem Biophys 502:53-59 (2010)
PubMed id: 20637176  
 
 
Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
B.S.Avvaru, D.J.Arenas, C.Tu, D.B.Tanner, R.McKenna, D.N.Silverman.
 
  ABSTRACT  
 
No abstract given.