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PDBsum entry 3kij

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
3kij
Jmol
Contents
Protein chains
171 a.a. *
Ligands
SO4
Waters ×517
* Residue conservation analysis
PDB id:
3kij
Name: Oxidoreductase
Title: Crystal structure of the human pdi-peroxidase
Structure: Probable glutathione peroxidase 8. Chain: a, b, c. Fragment: unp residues 38-209. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: homo sapiens. Gene: gpx8, gpx8_human, unq847/pro1785. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.80Å     R-factor:   0.211     R-free:   0.248
Authors: D.V.Nguyen,L.W.Ruddock
Key ref: V.D.Nguyen et al. (2011). Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation. J Mol Biol, 406, 503-515. PubMed id: 21215271 DOI: 10.1016/j.jmb.2010.12.039
Date:
02-Nov-09     Release date:   12-Jan-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q8TED1  (GPX8_HUMAN) -  Probable glutathione peroxidase 8
Seq:
Struc:
209 a.a.
171 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.11.1.9  - Glutathione peroxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O
2 × glutathione
+ H(2)O(2)
= glutathione disulfide
+ 2 × H(2)O
      Cofactor: Se(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   2 terms 
  Biochemical function     glutathione peroxidase activity     1 term  

 

 
    reference    
 
 
DOI no: 10.1016/j.jmb.2010.12.039 J Mol Biol 406:503-515 (2011)
PubMed id: 21215271  
 
 
Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation.
V.D.Nguyen, M.J.Saaranen, A.R.Karala, A.K.Lappi, L.Wang, I.B.Raykhel, H.I.Alanen, K.E.Salo, C.C.Wang, L.W.Ruddock.
 
  ABSTRACT  
 
No abstract given.