spacer
spacer

PDBsum entry 3k0r

Go to PDB code: 
protein links
Isomerase PDB id
3k0r
Jmol
Contents
Protein chain
164 a.a. *
Waters ×59
* Residue conservation analysis
PDB id:
3k0r
Name: Isomerase
Title: Cryogenic structure of cypa mutant arg55lys
Structure: Cyclophilin a. Chain: a. Synonym: peptidyl-prolyl cis-trans isomerase a, ppiase a, rotamase, cyclosporin a-binding protein. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppia, cypa. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.42Å     R-factor:   0.183     R-free:   0.236
Authors: J.S.Fraser,T.Alber
Key ref: J.S.Fraser et al. (2009). Hidden alternative structures of proline isomerase essential for catalysis. Nature, 462, 669.
Date:
25-Sep-09     Release date:   08-Dec-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P62937  (PPIA_HUMAN) -  Peptidyl-prolyl cis-trans isomerase A
Seq:
Struc:
165 a.a.
164 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   8 terms 
  Biological process     viral reproduction   18 terms 
  Biochemical function     protein binding     7 terms