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PDBsum entry 3iqk

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protein ligands metals links
Lyase PDB id
3iqk
Jmol
Contents
Protein chain
257 a.a. *
Ligands
TH7
D2S
GOL
SO4
Metals
_ZN
Waters ×311
* Residue conservation analysis
Superseded by: 4fik
PDB id:
3iqk
Name: Lyase
Title: Human carbonic anhydrase ii h64a complexed with thioxolone h products
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratas carbonic anhydrasE C, cac. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.20Å     R-factor:   0.125     R-free:   0.155
Authors: K.H.Sippel,C.Genis,L.Govindasamy,M.Agbandje-Mckenna,B.C.Trip R.Mckenna
Key ref: K.H.Sippel et al. (2010). Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II. J Phys Chem Lett, 1, 2898-2902. PubMed id: 20976122
Date:
20-Aug-09     Release date:   25-Aug-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
J Phys Chem Lett 1:2898-2902 (2010)
PubMed id: 20976122  
 
 
Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
K.H.Sippel, C.Genis, L.Govindasamy, M.Agbandje-McKenna, J.J.Kiddle, B.C.Tripp, R.McKenna.
 
  ABSTRACT  
 
No abstract given.