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PDBsum entry 3ikd

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protein ligands Protein-protein interface(s) links
Isomerase PDB id
3ikd
Jmol
Contents
Protein chain
113 a.a. *
Ligands
J9Z ×2
Waters ×474
* Residue conservation analysis
PDB id:
3ikd
Name: Isomerase
Title: Structure-based design of novel pin1 inhibitors (i)
Structure: Peptidyl-prolyl cis-trans isomerase nima- interacting 1. Chain: a, b. Fragment: unp residues 45-163, pin1 ppiase domain. Synonym: rotamase pin1, ppiase pin1. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pin1. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.00Å     R-factor:   0.203     R-free:   0.203
Authors: D.Matthews,S.Greasley,R.Ferre,H.Parge
Date:
05-Aug-09     Release date:   22-Sep-09    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q13526  (PIN1_HUMAN) -  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Seq:
Struc:
163 a.a.
113 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     isomerase activity     1 term