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PDBsum entry 3ihy

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protein Protein-protein interface(s) links
Transferase PDB id
3ihy
Jmol
Contents
Protein chain
536 a.a. *
Waters ×1
* Residue conservation analysis
PDB id:
3ihy
Name: Transferase
Title: Human pik3c3 crystal structure
Structure: Phosphatidylinositol 3-kinase catalytic subunit type 3. Chain: a, b, c, d, e. Fragment: unp residues 282-879. Synonym: ptdins-3-kinase type 3, pi3-kinase type 3, pi3k type 3, phosphoinositide-3-kinase class 3, phosphatidylinositol 3-kinase p100 subunit. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3c3, pik3c3a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.80Å     R-factor:   0.190     R-free:   0.255
Authors: M.I.Siponen,L.Tresaugues,C.H.Arrowsmith,H.Berglund, C.Bountra,R.Collins,A.M.Edwards,S.Flodin,A.Flores, S.Graslund,M.Hammarstrom,A.Johansson,I.Johansson, T.Karlberg,T.Kotenyova,A.Kotzsch,T.Kragh Nielsen,M.Moche, T.Nyman,C.Persson,A.K.Roos,J.Sagemark,H.Schueler,P.Schutz, A.G.Thorsell,S.Van Den Berg,J.Weigelt,M.Welin,M.Wisniewska, P.Nordlund,Structural Genomics Consortium (Sgc)
Key ref: M.I.Siponen et al. Human pik3c3 crystal structure. To be published, .
Date:
31-Jul-09     Release date:   13-Oct-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q8NEB9  (PK3C3_HUMAN) -  Phosphatidylinositol 3-kinase catalytic subunit type 3
Seq:
Struc:
 
Seq:
Struc:
887 a.a.
536 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.137  - Phosphatidylinositol 3-kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
1-Phosphatidyl-myo-inositol Metabolism
      Reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate
ATP
+ 1-phosphatidyl-1D-myo-inositol
= ADP
+ 1-phosphatidyl-1D-myo- inositol 3-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     phosphatidylinositol-mediated signaling   2 terms 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     2 terms