PDBsum entry: 3ihy

Transferase

PDB id: 3ihy

Contents

Protein chains

536 a.a. *

Waters ×1

* Residue conservation analysis

PDB id:

3ihy

Name:

Transferase

Title:

Human pik3c3 crystal structure

Structure:

Phosphatidylinositol 3-kinase catalytic subunit type 3. Chain: a, b, c, d, e. Fragment: unp residues 282-879. Synonym: ptdins-3-kinase type 3, pi3-kinase type 3, pi3k type 3, phosphoinositide-3-kinase class 3, phosphatidylinositol 3-kinase p100 subunit. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3c3, pik3c3a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.80Å R-factor: 0.190 R-free: 0.255

Authors:

M.I.Siponen,L.Tresaugues,C.H.Arrowsmith,H.Berglund, C.Bountra,R.Collins,A.M.Edwards,S.Flodin,A.Flores, S.Graslund,M.Hammarstrom,A.Johansson,I.Johansson, T.Karlberg,T.Kotenyova,A.Kotzsch,T.Kragh Nielsen,M.Moche, T.Nyman,C.Persson,A.K.Roos,J.Sagemark,H.Schueler,P.Schutz, A.G.Thorsell,S.Van Den Berg,J.Weigelt,M.Welin,M.Wisniewska, P.Nordlund,Structural Genomics Consortium (Sgc)

Key ref:

M.I.Siponen et al. Human pik3c3 crystal structure. To be published,

Date:

31-Jul-09 Release date: 13-Oct-09

Protein chains

Q8NEB9  (PK3C3_HUMAN) -  Phosphatidylinositol 3-kinase catalytic subunit type 3

Seq: 887 a.a.

Struc: 536 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.1.137 - Phosphatidylinositol 3-kinase.
• Pathway: 1-Phosphatidyl-myo-inositol Metabolism
• Reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: phosphatidylinositol-mediated signaling (2 terms)
• Biochemical function: binding (4 terms)