PDBsum entry: 3ibe

Transferase

PDB id: 3ibe

Contents

Protein chain

850 a.a. *

Ligands

SO4

L64

Waters ×42

* Residue conservation analysis

PDB id:

3ibe

Name:

Transferase

Title:

Crystal structure of a pyrazolopyrimidine inhibitor bound to pi3 kinase gamma

Structure:

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. Chain: a. Fragment: pi3 kinase gamma (unp residues 144 to 1102). Synonym: pi3-kinase p110 subunit gamma, ptdins-3-kinase subunit p110, pi3kgamma, pi3k, p120-pi3k. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3cg. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.80Å R-factor: 0.214 R-free: 0.277

Authors:

J.Bard,K.Svenson

Date:

15-Jul-09 Release date: 01-Sep-09

Protein chain

P48736  (PK3CG_HUMAN) -  Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Seq: 1102 a.a.

Struc: 850 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class 2: E.C.2.7.1.153 - Phosphatidylinositol-4,5-bisphosphate 3-kinase.
• Pathway: 1-Phosphatidyl-myo-inositol Metabolism
• Reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
• Enzyme class 3: E.C.2.7.11.1 - Non-specific serine/threonine protein kinase.
• Reaction: ATP + a protein = ADP + a phosphoprotein

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: phosphatidylinositol 3-kinase complex (1 term)
• Biological process: phosphatidylinositol-mediated signaling (2 terms)
• Biochemical function: binding (6 terms)