PDBsum entry: 3h6l

Transferase

PDB id: 3h6l

Contents

Protein chain

231 a.a. *

Ligands

SAM

Metals

_ZN ×3

Waters ×139

* Residue conservation analysis

PDB id:

3h6l

Name:

Transferase

Title:

Methyltransferase domain of human set domain-containing prot

Structure:

Histone-lysine n-methyltransferase setd2. Chain: a. Synonym: set domain-containing protein 2, hset2, huntingtin interacting protein b, huntingtin yeast partner b, huntingt interacting protein 1, hif-1, p231hbp, lysine n-methyltrans engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: setd2, hif1, hypb, kiaa1732, kmt3a, set2, hspc069. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.99Å R-factor: 0.226 R-free: 0.271

Authors:

M.F.Amaya,H.Zeng,F.Mackenzie,C.Bountra,J.Weigelt,C.H.Arrowsm A.M.Edwards,A.Bochkarev,J.Min,H.Wu,Structural Genomics Cons (Sgc)

Key ref:

H.Zeng et al. The crystal structure of methyltransferase domain of human set domain-Containing protein 2 in complex with s-Adenosyl-L-Methionine.. To be published,

Date:

23-Apr-09 Release date: 05-May-09

Protein chain

Q9BYW2  (SETD2_HUMAN) -  Histone-lysine N-methyltransferase SETD2

Seq: 2564 a.a.

Struc: 231 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.43 - Histone-lysine N-methyltransferase.
• Reaction: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone]

S-adenosyl-L-methionine (Bound ligand (Het Group name = SAM) corresponds exactly) + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: nucleus (1 term)
• Biochemical function: protein binding (2 terms)