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PDBsum entry 3h2p

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase PDB id
3h2p
Jmol
Contents
Protein chains
126 a.a. *
129 a.a. *
Ligands
MLI ×2
ACE
Metals
_ZN ×3
Waters ×259
* Residue conservation analysis
PDB id:
3h2p
Name: Oxidoreductase
Title: Human sod1 d124v variant
Structure: Superoxide dismutase [cu-zn]. Chain: a, b. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sod1. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Resolution:
1.55Å     R-factor:   0.155     R-free:   0.202
Authors: S.V.Seetharaman,D.D.Winkler,A.B.Taylor,X.Cao,L.J.Whitson, P.A.Doucette,J.S.Valentine,M.C.Carroll,V.C.Culotta,P.J.Hart
Key ref: S.V.Seetharaman et al. Structures of pathogenic sod1 mutants h80r and d124V: disrupted zinc-Binding and compromised post-Translati modification by the copper chaperone ccs. To be published, .
Date:
14-Apr-09     Release date:   05-May-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00441  (SODC_HUMAN) -  Superoxide dismutase [Cu-Zn]
Seq:
Struc:
154 a.a.
126 a.a.*
Protein chain
Pfam   ArchSchema ?
P00441  (SODC_HUMAN) -  Superoxide dismutase [Cu-Zn]
Seq:
Struc:
154 a.a.
129 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.1.15.1.1  - Superoxide dismutase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 superoxide + 2 H+ = O2 + H2O2
2 × superoxide
+ 2 × H(+)
= O(2)
+ H(2)O(2)
      Cofactor: Fe cation or Mn(2+) or (Zn(2+) and Cu cation)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   16 terms 
  Biological process     reactive oxygen species metabolic process   62 terms 
  Biochemical function     antioxidant activity     12 terms