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PDBsum entry 3gvg

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protein ligands Protein-protein interface(s) links
Isomerase PDB id
3gvg
Jmol
Contents
Protein chains
256 a.a. *
Ligands
GOL ×3
Waters ×650
* Residue conservation analysis
PDB id:
3gvg
Name: Isomerase
Title: Crystal structure of triosephosphate isomerase from mycobact tuberculosis
Structure: Triosephosphate isomerase. Chain: a, b. Synonym: tim, triose-phosphate isomerase. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: tpia, tpi, rv1438, mt1482, mtcy493.16c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.55Å     R-factor:   0.145     R-free:   0.169
Authors: Seattle Structural Genomics Center For Infectious Disease (S
Key ref: L.Baugh et al. (2015). Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 142-148. PubMed id: 25613812 DOI: 10.1016/j.tube.2014.12.003
Date:
31-Mar-09     Release date:   14-Apr-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam  
P9WG43  (TPIS_MYCTU) -  Triosephosphate isomerase
Seq:
Struc:
261 a.a.
256 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.5.3.1.1  - Triose-phosphate isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate
D-glyceraldehyde 3-phosphate
Bound ligand (Het Group name = GOL)
matches with 60.00% similarity
= glycerone phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   4 terms 
  Biological process     metabolic process   5 terms 
  Biochemical function     catalytic activity     4 terms  

 

 
    Added reference    
 
 
DOI no: 10.1016/j.tube.2014.12.003 Tuberculosis (Edinb) 95:142-148 (2015)
PubMed id: 25613812  
 
 
Increasing the structural coverage of tuberculosis drug targets.
L.Baugh, I.Phan, D.W.Begley, M.C.Clifton, B.Armour, D.M.Dranow, B.M.Taylor, M.M.Muruthi, J.Abendroth, J.W.Fairman, D.Fox, S.H.Dieterich, B.L.Staker, A.S.Gardberg, R.Choi, S.N.Hewitt, A.J.Napuli, J.Myers, L.K.Barrett, Y.Zhang, M.Ferrell, E.Mundt, K.Thompkins, N.Tran, S.Lyons-Abbott, A.Abramov, A.Sekar, D.Serbzhinskiy, D.Lorimer, G.W.Buchko, R.Stacy, L.J.Stewart, T.E.Edwards, W.C.Van Voorhis, P.J.Myler.
 
  ABSTRACT  
 
No abstract given.