spacer
spacer

PDBsum entry 3gtd

Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Lyase PDB id
3gtd
Jmol
Contents
Protein chains
455 a.a. *
400 a.a. *
Ligands
MLI ×2
Metals
_NA
Waters ×198
* Residue conservation analysis
PDB id:
3gtd
Name: Lyase
Title: 2.4 angstrom crystal structure of fumarate hydratase from ri prowazekii
Structure: Fumarate hydratase class ii. Chain: a, b. Synonym: fumarasE C. Engineered: yes
Source: Rickettsia prowazekii. Organism_taxid: 272947. Strain: madrid-e. Gene: fumc, rp665. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.40Å     R-factor:   0.194     R-free:   0.226
Authors: Seattle Structural Genomics Center For Infectious Disease (S
Key ref: I.Phan et al. (2011). Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria. Acta Crystallogr Sect F Struct Biol Cryst Commun, 67, 1123-1128. PubMed id: 21904061
Date:
27-Mar-09     Release date:   14-Jul-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9ZCQ4  (FUMC_RICPR) -  Fumarate hydratase class II
Seq:
Struc:
461 a.a.
455 a.a.
Protein chain
Pfam   ArchSchema ?
Q9ZCQ4  (FUMC_RICPR) -  Fumarate hydratase class II
Seq:
Struc:
461 a.a.
400 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.4.2.1.2  - Fumarate hydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Citric acid cycle
      Reaction: (S)-malate = fumarate + H2O
(S)-malate
Bound ligand (Het Group name = MLI)
matches with 60.00% similarity
= fumarate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   2 terms 
  Biological process     metabolic process   3 terms 
  Biochemical function     catalytic activity     3 terms  

 

 
    Added reference    
 
 
Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1123-1128 (2011)
PubMed id: 21904061  
 
 
Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria.
I.Phan, S.Subramanian, C.Olsen, T.E.Edwards, W.Guo, Y.Zhang, W.C.Van Voorhis, L.J.Stewart, P.J.Myler.
 
  ABSTRACT  
 
No abstract given.