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PDBsum entry 3gp0

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protein ligands metals links
Transferase/transferase inhibitor PDB id
3gp0
Jmol
Contents
Protein chain
333 a.a. *
Ligands
NIL
EDO
Metals
_CL
Waters ×211
* Residue conservation analysis
PDB id:
3gp0
Name: Transferase/transferase inhibitor
Title: Crystal structure of human mitogen activated protein kinase beta) in complex with nilotinib
Structure: Mitogen-activated protein kinase 11. Chain: a. Synonym: mapk11, mitogen-activated protein kinase p38 beta, kinase p38 beta, p38b, p38-2, stress-activated protein kina engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk11, prkm11, sapk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.90Å     R-factor:   0.181     R-free:   0.232
Authors: P.Filippakopoulos,A.Barr,O.Fedorov,T.Keates,M.Soundararajan, E.Salah,N.Burgess-Brown,E.Ugochukwu,A.C.W.Pike,J.Muniz,A.Ro A.Chaikuad,F.Von Delft,C.H.Arrowsmith,A.M.Edwards,J.Weigelt C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
Key ref: P.Filippakopoulos et al. Crystal structure of human mitogen activated protein kinase 11 (p38 beta) in complex with nilotinib. To be published, .
Date:
20-Mar-09     Release date:   07-Apr-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q15759  (MK11_HUMAN) -  Mitogen-activated protein kinase 11
Seq:
Struc:
364 a.a.
333 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   4 terms 
  Biological process     intracellular signal transduction   31 terms 
  Biochemical function     nucleotide binding     9 terms