PDBsum entry: 3gid

Ligase

PDB id: 3gid

Contents

Protein chains

460 a.a. *

Ligands

S1A ×2

Waters ×197

* Residue conservation analysis

PDB id:

3gid

Name:

Ligase

Title:

The biotin carboxylase (bc) domain of human acetyl-coa carboxylase 2 (acc2) in complex with soraphen a

Structure:

Acetyl-coa carboxylase 2. Chain: a, b. Fragment: bc domain (unp residues 238-760). Synonym: acc-beta, biotin carboxylase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: acacb, acc2, accb. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.30Å R-factor: 0.202 R-free: 0.242

Authors:

A.Price,R.Kulathila

Key ref:

B.Raymer et al. The biotin carboxylase (bc) domain of human acetyl-Coa carboxylase 2 (acc2) in complex with soraphen a. To be published,

Date:

05-Mar-09 Release date: 17-Mar-09

Protein chains

O00763  (ACACB_HUMAN) -  Acetyl-CoA carboxylase 2

Seq: 2458 a.a.

Struc: 460 a.a.

Enzyme reactions

• Enzyme class 1: E.C.6.3.4.14 - Biotin carboxylase.
• Reaction: ATP + biotin-[carboxyl-carrier-protein] + CO₂ = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]
• Enzyme class 2: E.C.6.4.1.2 - Acetyl-CoA carboxylase.
• Reaction: ATP + acetyl-CoA + HCO₃^- = ADP + phosphate + malonyl-CoA
• Cofactor: Biotin

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: metabolic process (1 term)
• Biochemical function: catalytic activity (4 terms)