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Cytokine/cytokine receptor
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PDB id
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3g9v
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Contents |
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173 a.a.
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134 a.a.
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176 a.a.
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* Residue conservation analysis
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PDB id:
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Cytokine/cytokine receptor
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Title:
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Crystal structure of a soluble decoy receptor il-22bp bound to interleukin-22
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Structure:
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Interleukin 22 receptor, alpha 2. Chain: a, c. Fragment: unp residues 21-231. Synonym: interleukin-22 binding protein, isoform cra_a. Engineered: yes. Interleukin-22. Chain: b, d. Fragment: unp residues 29-179. Synonym: il-22, il-10-related t-cell-derived-inducible
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: il22ra2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: il22.
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Resolution:
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2.76Å
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R-factor:
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0.216
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R-free:
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0.282
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Authors:
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P.R.De Moura,L.Watanabe,L.Bleicher,D.Colau,J.-C.Renauld, I.Polikarpov
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Key ref:
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P.R.de Moura
et al.
(2009).
Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22.
Febs Lett,
583,
1072-1077.
PubMed id:
DOI:
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Date:
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14-Feb-09
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Release date:
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14-Apr-09
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PROCHECK
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Headers
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References
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Q969J5
(I22R2_HUMAN) -
Interleukin-22 receptor subunit alpha-2
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Seq:
Struc:
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263 a.a.
173 a.a.
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Gene Ontology (GO) functional annotation
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Cellular component
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extracellular region
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1 term
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Biochemical function
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protein binding
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1 term
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DOI no:
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Febs Lett
583:1072-1077
(2009)
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PubMed id:
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Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22.
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P.R.de Moura,
L.Watanabe,
L.Bleicher,
D.Colau,
L.Dumoutier,
M.M.Lemaire,
J.C.Renauld,
I.Polikarpov.
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ABSTRACT
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Interleukin-22 (IL-22) plays an important role in the regulation of immune and
inflammatory responses in mammals. The IL-22 binding protein (IL-22BP), a
soluble receptor that specifically binds IL-22, prevents the
IL-22/interleukin-22 receptor 1 (IL-22R1)/interleukin-10 receptor 2 (IL-10R2)
complex assembly and blocks IL-22 biological activity. Here we present the
crystal structure of the IL-22/IL-22BP complex at 2.75 A resolution. The
structure reveals IL-22BP residues critical for IL-22 binding, which were
confirmed by site-directed mutagenesis and functional studies. Comparison of
IL-22/IL-22BP and IL-22/IL-22R1 crystal structures shows that both receptors
display an overlapping IL-22 binding surface, which is consistent with the
inhibitory role played by IL-22 binding protein.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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M.M.Lemaire,
A.Vanhaudenarde,
Y.Nizet,
L.Dumoutier,
and
J.C.Renauld
(2011).
Induction of autoantibodies against mouse soluble proteins after immunization with living cells presenting the autoantigen at the cell surface in fusion with a human type 2 transmembrane protein.
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J Immunol Methods, 367,
56-62.
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W.Ouyang,
S.Rutz,
N.K.Crellin,
P.A.Valdez,
and
S.G.Hymowitz
(2011).
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
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Annu Rev Immunol, 29,
71.
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X.Zhang,
P.Angkasekwinai,
C.Dong,
and
H.Tang
(2011).
Structure and function of interleukin-17 family cytokines.
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Protein Cell, 2,
26-40.
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A.Zdanov
(2010).
Structural analysis of cytokines comprising the IL-10 family.
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Cytokine Growth Factor Rev, 21,
325-330.
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D.B.Trivella,
J.R.Ferreira-Júnior,
L.Dumoutier,
J.C.Renauld,
and
I.Polikarpov
(2010).
Structure and function of interleukin-22 and other members of the interleukin-10 family.
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Cell Mol Life Sci, 67,
2909-2935.
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E.Witte,
K.Witte,
K.Warszawska,
R.Sabat,
and
K.Wolk
(2010).
Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection.
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Cytokine Growth Factor Rev, 21,
365-379.
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J.L.Galzi,
M.Hachet-Haas,
D.Bonnet,
F.Daubeuf,
S.Lecat,
M.Hibert,
J.Haiech,
and
N.Frossard
(2010).
Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications.
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| |
Pharmacol Ther, 126,
39-55.
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K.Wolk,
E.Witte,
K.Witte,
K.Warszawska,
and
R.Sabat
(2010).
Biology of interleukin-22.
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Semin Immunopathol, 32,
17-31.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
