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PDBsum entry 3eoe

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protein ligands Protein-protein interface(s) links
Transferase PDB id
3eoe
Jmol
Contents
Protein chains
472 a.a. *
382 a.a. *
Ligands
GOL ×3
Waters ×639
* Residue conservation analysis
PDB id:
3eoe
Name: Transferase
Title: Crystal structure of pyruvate kinase from toxoplasma gondii,
Structure: Pyruvate kinase. Chain: a, b, c, d. Fragment: sequence database residues 39-531. Engineered: yes
Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: pk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.31Å     R-factor:   0.208     R-free:   0.253
Authors: A.K.Wernimont,J.Lew,I.Kozieradzki,G.Wasney,A.Hassani,M.Vedad D.Cossar,M.Schapiro,A.Bochkarev,C.H.Arrowsmith,C.Bountra,J. A.M.Edwards,R.Hui,J.Pizarro,Structural Genomics Consortium
Key ref: R.Bakszt et al. (2010). The crystal structure of Toxoplasma gondii pyruvate kinase 1. PLoS One, 5, e12736. PubMed id: 20856875
Date:
26-Sep-08     Release date:   14-Oct-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q969A2  (Q969A2_TOXGO) -  Pyruvate kinase
Seq:
Struc:
 
Seq:
Struc:
531 a.a.
472 a.a.
Protein chain
Pfam   ArchSchema ?
Q969A2  (Q969A2_TOXGO) -  Pyruvate kinase
Seq:
Struc:
 
Seq:
Struc:
531 a.a.
382 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.2.7.1.40  - Pyruvate kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + pyruvate = ADP + phosphoenolpyruvate
ATP
+
pyruvate
Bound ligand (Het Group name = GOL)
matches with 71.43% similarity
= ADP
+ phosphoenolpyruvate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     phosphorylation   2 terms 
  Biochemical function     catalytic activity     6 terms  

 

 
    reference    
 
 
PLoS One 5:e12736 (2010)
PubMed id: 20856875  
 
 
The crystal structure of Toxoplasma gondii pyruvate kinase 1.
R.Bakszt, A.Wernimont, A.Allali-Hassani, M.W.Mok, T.Hills, R.Hui, J.C.Pizarro.
 
  ABSTRACT  
 
No abstract given.