spacer
spacer

PDBsum entry 3eoc

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Transferase/cell cycle PDB id
3eoc
Jmol
Contents
Protein chains
295 a.a. *
257 a.a. *
Ligands
T2A ×2
* Residue conservation analysis
PDB id:
3eoc
Name: Transferase/cell cycle
Title: Cdk2/cyclina complexed with a imidazo triazin-2-amine
Structure: Cell division protein kinase 2. Chain: a, c. Synonym: p33 protein kinase. Engineered: yes. Cyclin-a2. Chain: b, d. Fragment: proteolytic fragment: residues 173-432. Synonym: cyclin-a. Engineered: yes
Source: Homo sapiens. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli.
Resolution:
3.20Å     R-factor:   0.216     R-free:   0.238
Authors: M.Cheung,K.Kuntz,M.Pobanz,J.Salovich,B.Wilson,W.Andrews,L.Sh A.Epperly,D.Hassler,M.Leesnitzer,J.Smith,G.Smith,T.Lansing,
Key ref: M.Cheung et al. (2008). Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg Med Chem Lett, 18, 6214-6217. PubMed id: 18929484 DOI: 10.1016/j.bmcl.2008.09.100
Date:
26-Sep-08     Release date:   04-Nov-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
295 a.a.
Protein chains
Pfam   ArchSchema ?
P20248  (CCNA2_HUMAN) -  Cyclin-A2
Seq:
Struc:
432 a.a.
257 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, C: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   30 terms 
  Biochemical function     nucleotide binding     13 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.bmcl.2008.09.100 Bioorg Med Chem Lett 18:6214-6217 (2008)
PubMed id: 18929484  
 
 
Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
M.Cheung, K.W.Kuntz, M.Pobanz, J.M.Salovich, B.J.Wilson, C.W.Andrews, L.M.Shewchuk, A.H.Epperly, D.F.Hassler, M.A.Leesnitzer, J.L.Smith, G.K.Smith, T.J.Lansing, R.A.Mook.
 
  ABSTRACT  
 
The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.