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PDBsum entry 3eiy

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protein ligands metals links
Hydrolase PDB id
3eiy
Jmol
Contents
Protein chain
174 a.a. *
Ligands
POP
PG4
PEG ×2
Metals
__K
_NA ×2
Waters ×112
* Residue conservation analysis
PDB id:
3eiy
Name: Hydrolase
Title: Crystal structure of inorganic pyrophosphatase from burkhold pseudomallei with bound pyrophosphate
Structure: Inorganic pyrophosphatase. Chain: a. Engineered: yes
Source: Burkholderia pseudomallei 1710b. Organism_taxid: 320372. Gene: ppa, burps1710b_1237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.10Å     R-factor:   0.213     R-free:   0.249
Authors: Seattle Structural Genomics Center For Infectious Disease (S
Key ref: W.C.Van Voorhis et al. (2009). The role of medical structural genomics in discovering new drugs for infectious diseases. PLoS Comput Biol, 5, e1000530. PubMed id: 19855826
Date:
17-Sep-08     Release date:   30-Sep-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q3JUV5  (Q3JUV5_BURP1) -  Inorganic pyrophosphatase
Seq:
Struc:
175 a.a.
174 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.6.1.1  - Inorganic diphosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Diphosphate + H2O = 2 phosphate
Diphosphate
Bound ligand (Het Group name = POP)
corresponds exactly
+ H(2)O
= 2 × phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     phosphate-containing compound metabolic process   1 term 
  Biochemical function     hydrolase activity     4 terms  

 

 
    Added reference    
 
 
PLoS Comput Biol 5:e1000530 (2009)
PubMed id: 19855826  
 
 
The role of medical structural genomics in discovering new drugs for infectious diseases.
W.C.Van Voorhis, W.G.Hol, P.J.Myler, L.J.Stewart.
 
  ABSTRACT  
 
No abstract given.