PDBsum entry 3eiy

Hydrolase

PDB id: 3eiy

Contents

Protein chain

174 a.a. *

Ligands

POP

PG4

PEG ×2

Metals

__K

_NA ×2

Waters ×112

* Residue conservation analysis

PDB id:

3eiy

Name:

Hydrolase

Title:

Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei with bound pyrophosphate

Structure:

Inorganic pyrophosphatase. Chain: a. Engineered: yes

Source:

Burkholderia pseudomallei 1710b. Organism_taxid: 320372. Gene: ppa, burps1710b_1237. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.10Å R-factor: 0.213 R-free: 0.249

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

W.C.Van Voorhis et al. (2009). The role of medical structural genomics in discovering new drugs for infectious diseases. Plos Comput Biol, 5, e1000530. PubMed id: 19855826

Date:

17-Sep-08 Release date: 30-Sep-08

Protein chain

Q3JUV5  (Q3JUV5_BURP1) -  Inorganic pyrophosphatase from Burkholderia pseudomallei (strain 1710b)

Seq: 175 a.a.

Struc: 174 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.1.1 - inorganic diphosphatase.
• Reaction: diphosphate + H2O = 2 phosphate + H⁺

diphosphate (Bound ligand (Het Group name = POP) corresponds exactly) + H2O = 2 × phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Plos Comput Biol 5:e1000530 (2009)

PubMed id: 19855826

The role of medical structural genomics in discovering new drugs for infectious diseases.

W.C.Van Voorhis, W.G.Hol, P.J.Myler, L.J.Stewart.

ABSTRACT

No abstract given.