PDBsum entry: 3ef1

Hydrolase

PDB id: 3ef1

Contents

Protein chain

372 a.a. *

Metals

_MG

Waters ×163

* Residue conservation analysis

PDB id:

3ef1

Name:

Hydrolase

Title:

The structure of fcp1, an essential RNA polymerase ii ctd phosphatase

Structure:

RNA polymerase ii subunit a c-terminal domain phosphatase. Chain: a. Fragment: fcp1 homology domain, catalytically active fragment, unp residues 140-580. Synonym: ctd phosphatase fcp1. Engineered: yes

Source:

Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: fcp1, spac19b12.05c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.15Å R-factor: 0.211 R-free: 0.234

Authors:

A.Ghosh,C.D.Lima

Key ref:

A.Ghosh et al. (2005). The structure of fcp1, An essential RNA polymerase ii ctd phosphatase. Mol.Cell, 32,

Date:

07-Sep-08 Release date: 02-Dec-08

Protein chain

Q9P376  (FCP1_SCHPO) -  RNA polymerase II subunit A C-terminal domain phosphatase

Seq: 723 a.a.

Struc: 372 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.3.16 - Phosphoprotein phosphatase.
• Reaction: A phosphoprotein + H₂O = a protein + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: intracellular (2 terms)
• Biochemical function: phosphoprotein phosphatase activity (1 term)