PDBsum entry: 3dr3

Oxidoreductase

PDB id: 3dr3

Contents

Protein chain

335 a.a. *

Ligands

MLT

Metals

_NA ×2

Waters ×392

* Residue conservation analysis

PDB id:

3dr3

Name:

Oxidoreductase

Title:

Structure of idp00107, a potential n-acetyl-gamma- glutamylphosphate reductase from shigella flexneri

Structure:

N-acetyl-gamma-glutamyl-phosphate reductase. Chain: a. Synonym: agpr, n-acetyl-glutamate semialdehyde dehydrogenase, nagsa dehydrogenase. Engineered: yes

Source:

Shigella flexneri. Organism_taxid: 623. Strain: 2a str. 2457t. Gene: argc, sf4035, s3711. Expressed in: escherichia coli.

Resolution:

2.00Å R-factor: 0.168 R-free: 0.216

Authors:

A.U.Singer,T.Skarina,O.Onopriyenko,A.M.Edwards,W.F.Anderson, A.Savchenko,Center For Structural Genomics Of Infectious Diseases (Csgid)

Key ref:

A.U.Singer et al. Structure of idp00107, A potential n-Acetyl-Gamma-Glutamylphosphate reductase from shigella flexneri. To be published,

Date:

10-Jul-08 Release date: 05-Aug-08

Protein chain

P59310  (ARGC_SHIFL) -  N-acetyl-gamma-glutamyl-phosphate reductase

Seq: 334 a.a.

Struc: 335 a.a.

Enzyme reactions

• Enzyme class: E.C.1.2.1.38 - N-acetyl-gamma-glutamyl-phosphate reductase.
• Pathway: Ornithine Biosynthesis
• Reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP⁺ + phosphate = N-acetyl-5- glutamyl phosphate + NADPH

N-acetyl-L-glutamate 5-semialdehyde (Bound ligand (Het Group name = MLT) matches with 40.00% similarity) + NADP(+) + phosphate = N-acetyl-5- glutamyl phosphate + NADPH

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (1 term)
• Biological process: oxidation-reduction process (4 terms)
• Biochemical function: nucleotide binding (6 terms)