PDBsum entry: 3dlm

Transferase

PDB id: 3dlm

Contents

Protein chain

208 a.a. *

Waters ×212

* Residue conservation analysis

PDB id:

3dlm

Name:

Transferase

Title:

Crystal structure of tudor domain of human histone-lysine n- methyltransferase setdb1

Structure:

Histone-lysine n-methyltransferase setdb1. Chain: a. Synonym: set domain bifurcated 1, erg-associated protein with set domain, eset, histone h3-k9 methyltransferase 4, h3-k9-hmtase 4, lysine n- methyltransferase 1e. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Organism_taxid: 9606. Gene: setdb1, kiaa0067, kmt1e. Expressed in: escherichia coli.

Resolution:

1.77Å R-factor: 0.210 R-free: 0.237

Authors:

M.F.Amaya,L.Dombrovski,P.Loppnau,C.Bountra,J.Weigelt, C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,J.Min,H.Wu, Structural Genomics Consortium (Sgc)

Key ref:

L.Dombrovski et al. The crystal structure of tudor domain of human histone-Lysine n-Methyltransferase setdb1.. To be published,

Date:

27-Jun-08 Release date: 12-Aug-08

Protein chain

Q15047  (SETB1_HUMAN) -  Histone-lysine N-methyltransferase SETDB1

Seq: 1291 a.a.

Struc: 208 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.1.1.43 - Histone-lysine N-methyltransferase.
• Reaction: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone]

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biochemical function: nucleic acid binding (1 term)