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PDBsum entry 3d4p

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
3d4p
Jmol
Contents
Protein chains
307 a.a. *
Ligands
NAD ×2
PYR ×2
Waters ×305
* Residue conservation analysis
PDB id:
3d4p
Name: Oxidoreductase
Title: Crystal structure of lactate dehydrogenase from staphylococcus aureus complexed with NAD and pyruvate
Structure: L-lactate dehydrogenase 1. Chain: a, b. Synonym: l-ldh 1. Engineered: yes
Source: Staphylococcus aureus subsp. Aureus col. Organism_taxid: 93062. Gene: ldh1, sacol0222. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.80Å     R-factor:   0.164     R-free:   0.188
Authors: V.L.Schramm,S.C.Almo,J.A.Gutierrez,M.Ho
Key ref: V.L.Schramm et al. Crystal structure of lactate dehydrogenase from staphylococcus aureus complexed with NAD and pyruvate. To be published, .
Date:
14-May-08     Release date:   02-Jun-09    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q5HJD7  (LDH1_STAAC) -  L-lactate dehydrogenase 1
Seq:
Struc:
317 a.a.
307 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.27  - L-lactate dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: (S)-lactate + NAD+ = pyruvate + NADH
(S)-lactate
Bound ligand (Het Group name = PYR)
corresponds exactly
+
NAD(+)
Bound ligand (Het Group name = NAD)
corresponds exactly
= pyruvate
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     response to stress   5 terms 
  Biochemical function     catalytic activity     4 terms