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PDBsum entry 3d2k
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protein ligands links
Transferase PDB id
3d2k

 

 

 

 

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Contents
Protein chain
245 a.a. *
Ligands
AK4
Waters ×60
* Residue conservation analysis
PDB id:
3d2k
Name: Transferase
Title: Crystal structure of mouse aurora a (asn186->gly, lys240->arg, met302- >leu) in complex with [7-(2-{2-[3-(3-chloro-phenyl)-ureido]-thiazol- 5-yl}-ethylamino)-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid
Structure: Serine/threonine kinase 6. Chain: a. Fragment: aurora a kinase domain, unp residues 116-382. Engineered: yes. Mutation: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: aurka, stk6. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: n-terminal gst fusion
Resolution:
2.50Å     R-factor:   0.223     R-free:   0.273
Authors: R.A.Elling,J.D.Oslob,C.Yu,M.J.Romanowski
Key ref: J.D.Oslob et al. Discovery of aurora-A-Selective inhibitors. To be published, .
Date:
08-May-08     Release date:   12-May-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P97477  (AURKA_MOUSE) -  Aurora kinase A from Mus musculus
Seq:
Struc: 		395 a.a.
245 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.1  - non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
L-seryl-[protein]
 + ATP
 = O-phospho-L-seryl-[protein]
 + ADP
 + H(+)
L-threonyl-[protein]
 + ATP
 = O-phospho-L-threonyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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