spacer
spacer

PDBsum entry 3cyn

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
3cyn
Jmol
Contents
Protein chains
174 a.a. *
Ligands
SO4 ×6
GOL ×3
Waters ×242
* Residue conservation analysis
PDB id:
3cyn
Name: Oxidoreductase
Title: The structure of human gpx8
Structure: Probable glutathione peroxidase 8. Chain: a, b, c. Fragment: residues 44-209. Engineered: yes
Source: Homo sapiens. Human. Gene: loc493869. Expressed in: escherichia coli.
Resolution:
2.00Å     R-factor:   0.172     R-free:   0.199
Authors: K.L.Kavanagh,C.Johansson,W.W.Yue,G.Kochan,A.C.W.Pike,J.Murra A.K.Roos,P.Filippakopoulos,F.Von Delft,C.H.Arrowsmith,M.Wik A.M.Edwards,C.Bountra,U.Oppermann,Structural Genomics Conso (Sgc)
Key ref: K.L.Kavanagh et al. The structure of human gpx8. To be published, .
Date:
25-Apr-08     Release date:   12-Aug-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q8TED1  (GPX8_HUMAN) -  Probable glutathione peroxidase 8
Seq:
Struc:
209 a.a.
174 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 9 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.11.1.9  - Glutathione peroxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O
2 × glutathione
+ H(2)O(2)
= glutathione disulfide
+ 2 × H(2)O
      Cofactor: Selenium
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   2 terms 
  Biochemical function     glutathione peroxidase activity     1 term